From the I-495 beltway take I-270 north towards Frederick.

After about 32 miles, I-270 intersects I-70 and becomes US-40 west (do not take I-70).

After about 1 mile, take the US-340 west exit towards Harper?s Ferry.

After about 22 miles, turn right onto WV-230 north towards Shepherdstown.

Stay on 230 for about 10 miles until it ends in Shepherdstown at the intersection of German and Duke Streets.  You will be at a 4-way stop intersection and the inn will be across the intersection, on the corner, to your left.  Make a left turn onto Duke Street and park either on the right side of the street next to the inn or in the gravel lot at the rear of the inn's yard.

The trip is a little under 80 miles and should take about 2 hours.